Arch Dis Child Fetal Neonatal Ed 89:F445–F450Įvensen KA, Vik T, Helbostad J, et al (2004) Motor skills in adolescents with low birth weight. Indredavik MS, Vik T, Heyerdahl S, et al (2004) Psychiatric symptoms and disorders in adolescents with low birth weight. Kutschera J, Urlesberger B, Maurer U, et al (2002) Small for gestational age – somatic, neurological and cognitive development until adulthood. Hollo O, Rautava P, Korhonen T, et al (2002) Academic achievement of small-for-gestational-age children at age 10 years. Skranes JS, Vik T, Nilsen G, et al (1993) Cerebral magnetic-resonance-imaging (MRI) and mental and motor function of very-low-birth-weight infants at one-year of corrected age.
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Small, yet systematic, differences in brain metabolite distribution among the groups were confirmed by PNN analysis. By application of PNN, a correct classification of 52 of the 54 adolescents with a sensitivity and specificity exceeding 93% for all groups was achieved. No significant difference in the peak area ratios could be found using the Kruskal-Wallis test. Probabilistic neural network (PNN) analysis was performed utilizing the chemical shift region containing resonances from NAA, Cho and Cr as inputs. Peak areas of N-acetyl aspartate (NAA), choline (Cho) and creatine (Cr) were determined, and the peak area ratio of NAA to Cr, total Cho to Cr, or NAA to Cho calculated. MR spectra were acquired from volumes localized in the left frontal lobe, containing mainly white matter (54 subjects). To investigate possible brain metabolite differences in adolescents with VLBW, SGA at term and controls by proton in vivo magnetic resonance spectroscopy (MRS) at 1.5 T.
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Children with very low birth weight (VLBW) have a significantly increased risk of later neurodevelopmental problems, while infants born small for gestational age (SGA) at term are also at some risk of developing neurological impairment.